:root {
  color-scheme: light;
  --bg: #f6f7f9;
  --surface: #ffffff;
  --surface-strong: #f0f4f2;
  --line: #d8dedb;
  --line-strong: #b7c4be;
  --text: #16211d;
  --muted: #65736d;
  --teal: #087f72;
  --teal-soft: #dcefeb;
  --green: #247a44;
  --amber: #b86712;
  --blue-soft: #eef2f8;
  --blue-text: #30516f;
  --shadow: 0 12px 30px rgba(20, 31, 27, 0.08);
}

* {
  box-sizing: border-box;
}

body {
  margin: 0;
  background: var(--bg);
  color: var(--text);
  font-family:
    Inter, ui-sans-serif, system-ui, -apple-system, BlinkMacSystemFont, "Segoe UI",
    sans-serif;
  line-height: 1.4;
}

button,
input,
select {
  font: inherit;
}

button {
  cursor: pointer;
}

button:disabled {
  cursor: default;
  opacity: 0.48;
}

a {
  color: var(--teal);
  text-decoration: none;
}

a:hover {
  text-decoration: underline;
}

.loading {
  color: var(--muted);
  padding: 32px;
}

.shell {
  display: grid;
  grid-template-columns: var(--sidebar-width, 330px) minmax(520px, 1fr);
  min-height: 100vh;
}

.shell.has-detail {
  grid-template-columns: var(--sidebar-width, 330px) minmax(520px, 1fr) 8px var(--detail-width, 430px);
}

.shell.is-sidebar-collapsed {
  --sidebar-width: 68px;
}

.sidebar,
.detail-panel {
  background: var(--surface);
  border-color: var(--line);
  height: 100vh;
  overflow: auto;
  position: sticky;
  top: 0;
}

.sidebar {
  border-right: 1px solid var(--line);
  padding: 22px;
}

.shell.is-sidebar-collapsed .sidebar {
  overflow: hidden;
  padding: 16px 10px;
}

.detail-panel {
  border-left: 1px solid var(--line);
  padding: 22px;
}

.detail-resizer {
  background: var(--bg);
  border-left: 1px solid var(--line);
  border-right: 1px solid var(--line);
  cursor: col-resize;
  height: 100vh;
  position: sticky;
  top: 0;
}

.detail-resizer::after {
  background: var(--line-strong);
  border-radius: 2px;
  content: "";
  display: block;
  height: 44px;
  left: 50%;
  position: absolute;
  top: 50%;
  transform: translate(-50%, -50%);
  width: 3px;
}

.detail-resizer:hover::after,
.detail-resizer:focus-visible::after,
body.is-resizing-detail .detail-resizer::after {
  background: var(--teal);
}

body.is-resizing-detail {
  cursor: col-resize;
  user-select: none;
}

.workspace {
  min-width: 0;
  padding: 22px;
}

.active-filters {
  align-items: start;
  display: flex;
  gap: 10px;
  justify-content: space-between;
  margin-bottom: 12px;
}

.active-filter-list {
  display: flex;
  flex-wrap: wrap;
  gap: 7px;
  min-width: 0;
}

.filter-chip,
.clear-all-filters {
  align-items: center;
  background: #ffffff;
  border: 1px solid var(--line-strong);
  border-radius: 7px;
  color: var(--text);
  display: inline-flex;
  gap: 7px;
  min-width: 0;
  min-height: 32px;
  padding: 6px 9px;
}

.filter-chip {
  max-width: 260px;
  overflow: hidden;
}

.filter-chip:hover,
.clear-all-filters:hover {
  background: var(--surface-strong);
}

.filter-chip span {
  color: var(--muted);
  flex: 0 0 auto;
  font-size: 11px;
  font-weight: 900;
  letter-spacing: 0;
  text-transform: uppercase;
}

.filter-chip strong {
  font-size: 13px;
  font-weight: 800;
  min-width: 0;
  overflow: hidden;
  text-overflow: ellipsis;
  white-space: nowrap;
}

.filter-chip::after {
  background:
    linear-gradient(45deg, transparent 42%, currentColor 42%, currentColor 58%, transparent 58%),
    linear-gradient(-45deg, transparent 42%, currentColor 42%, currentColor 58%, transparent 58%);
  content: "";
  flex: 0 0 auto;
  height: 9px;
  opacity: 0.55;
  width: 9px;
}

.clear-all-filters {
  color: var(--teal);
  flex: 0 0 auto;
  font-size: 13px;
  font-weight: 900;
}

.sidebar-top {
  align-items: start;
  display: grid;
  gap: 10px;
  grid-template-columns: minmax(0, 1fr) 38px;
  margin-bottom: 22px;
}

.sidebar-toggle {
  align-items: center;
  background: #ffffff;
  border: 1px solid var(--line-strong);
  border-radius: 7px;
  color: var(--muted);
  display: grid;
  height: 38px;
  justify-content: center;
  padding: 0;
  width: 38px;
}

.sidebar-toggle:hover {
  background: var(--surface-strong);
  color: var(--teal);
}

.sidebar-toggle-icon {
  border-bottom: 2px solid currentColor;
  border-right: 2px solid currentColor;
  height: 8px;
  transform: rotate(135deg);
  width: 8px;
}

.shell.is-sidebar-collapsed .sidebar-top {
  gap: 12px;
  grid-template-columns: 1fr;
  justify-items: center;
  margin-bottom: 0;
}

.shell.is-sidebar-collapsed .sidebar-toggle-icon {
  transform: rotate(-45deg);
}

.shell.is-sidebar-collapsed .brand-title,
.shell.is-sidebar-collapsed .sidebar-content {
  display: none;
}

.brand-block {
  align-items: start;
  display: grid;
  gap: 12px;
  grid-template-columns: 58px minmax(0, 1fr);
  margin-bottom: 0;
}

.shell.is-sidebar-collapsed .brand-block {
  grid-template-columns: 44px;
}

.brand-mark {
  align-items: center;
  background: var(--teal);
  border-radius: 8px;
  display: grid;
  height: 58px;
  justify-content: center;
  padding: 4px;
  width: 58px;
}

.shell.is-sidebar-collapsed .brand-mark {
  height: 44px;
  padding: 3px;
  width: 44px;
}

.brand-mark svg {
  display: block;
  height: 100%;
  overflow: visible;
  width: 100%;
}

.network-lines {
  fill: none;
  stroke: rgba(255, 255, 255, 0.68);
  stroke-linecap: round;
  stroke-linejoin: round;
  stroke-width: 1.9;
}

.network-nodes {
  fill: #ffffff;
}

h1,
h2,
h3,
p {
  margin: 0;
}

h1 {
  font-size: 21px;
  letter-spacing: 0;
}

.brand-block p,
.panel-header p,
.results-toolbar p {
  color: var(--muted);
  font-size: 13px;
  margin-top: 2px;
}

.filters {
  display: grid;
  gap: 15px;
}

.field {
  display: grid;
  gap: 7px;
}

.field > span,
.filter-header > span,
.sort-control > span {
  color: var(--muted);
  font-size: 12px;
  font-weight: 800;
  letter-spacing: 0;
  text-transform: uppercase;
}

.field strong {
  color: var(--text);
  font-weight: 800;
  margin-left: 4px;
}

input,
select {
  background: #ffffff;
  border: 1px solid var(--line-strong);
  border-radius: 7px;
  color: var(--text);
  min-height: 38px;
  outline: none;
  padding: 8px 10px;
  width: 100%;
}

input:focus,
select:focus,
button:focus-visible {
  border-color: var(--teal);
  box-shadow: 0 0 0 3px var(--teal-soft);
  outline: none;
}

input[type="range"] {
  accent-color: var(--teal);
  border: 0;
  padding: 0;
}

.filter-header {
  align-items: center;
  display: flex;
  gap: 8px;
  justify-content: space-between;
}

.filter-toggle {
  align-items: center;
  background: #ffffff;
  border: 1px solid var(--line-strong);
  border-radius: 7px;
  color: var(--text);
  display: grid;
  gap: 8px;
  grid-template-columns: minmax(0, 1fr) auto 12px;
  min-height: 38px;
  padding: 8px 10px;
  text-align: left;
  width: 100%;
}

.filter-toggle span:first-child {
  color: var(--muted);
  font-size: 12px;
  font-weight: 800;
  letter-spacing: 0;
  text-transform: uppercase;
}

.filter-toggle strong {
  color: var(--text);
  font-size: 13px;
  font-weight: 800;
  margin-left: 0;
  overflow: hidden;
  text-overflow: ellipsis;
  white-space: nowrap;
}

.chevron {
  border-bottom: 2px solid var(--muted);
  border-right: 2px solid var(--muted);
  height: 7px;
  transform: rotate(45deg) translateY(-2px);
  width: 7px;
}

.checkbox-field.is-open .chevron {
  transform: rotate(225deg) translate(-2px, -1px);
}

.mini-button {
  background: transparent;
  border: 0;
  color: var(--teal);
  font-size: 12px;
  font-weight: 800;
  padding: 2px 0;
}

.filter-count {
  color: var(--muted);
  font-size: 12px;
}

.checkbox-list {
  background: #ffffff;
  border: 1px solid var(--line);
  border-radius: 8px;
  display: none;
  gap: 1px;
  max-height: 132px;
  overflow: auto;
  padding: 5px;
}

.checkbox-field.is-open .checkbox-list {
  display: grid;
}

.checkbox-list.is-tall {
  max-height: 190px;
}

.check-row {
  align-items: center;
  border-radius: 6px;
  display: grid;
  gap: 8px;
  grid-template-columns: 16px minmax(0, 1fr);
  min-height: 30px;
  padding: 5px 6px;
}

.check-row:hover {
  background: var(--surface-strong);
}

.check-row input {
  accent-color: var(--teal);
  height: 15px;
  min-height: 0;
  padding: 0;
  width: 15px;
}

.check-row span {
  overflow: hidden;
  text-overflow: ellipsis;
  white-space: nowrap;
}

.site-list {
  max-height: 210px;
}

.site-children {
  border-left: 1px solid var(--line);
  display: grid;
  margin: 0 0 3px 14px;
  padding-left: 8px;
}

.site-parent span {
  font-weight: 800;
}

.site-parent em {
  color: var(--muted);
  font-style: normal;
  font-weight: 700;
}

.site-child {
  color: var(--muted);
}

.empty-filter {
  color: var(--muted);
  font-size: 13px;
  padding: 8px;
}

.segmented {
  background: var(--surface-strong);
  border: 1px solid var(--line);
  border-radius: 8px;
  display: grid;
  gap: 2px;
  grid-template-columns: repeat(3, 1fr);
  padding: 3px;
}

.segmented button {
  background: transparent;
  border: 0;
  border-radius: 6px;
  color: var(--muted);
  min-height: 32px;
  padding: 6px 8px;
}

.segmented button.is-active {
  background: #ffffff;
  box-shadow: 0 1px 4px rgba(18, 30, 25, 0.12);
  color: var(--text);
  font-weight: 800;
}

.reset-button,
.ghost-button,
.pagination button {
  background: #ffffff;
  border: 1px solid var(--line-strong);
  border-radius: 7px;
  color: var(--text);
  min-height: 36px;
  padding: 8px 11px;
}

.reset-button:hover,
.ghost-button:hover:not(:disabled),
.pagination button:hover:not(:disabled) {
  background: var(--surface-strong);
}

.results-panel {
  background: var(--surface);
  border: 1px solid var(--line);
  border-radius: 8px;
  box-shadow: var(--shadow);
}

.panel-header,
.results-toolbar,
.detail-header {
  align-items: center;
  display: flex;
  gap: 12px;
  justify-content: space-between;
}

.panel-header {
  margin-bottom: 12px;
}

.panel-header h2,
.results-toolbar h2,
.detail-header h2 {
  font-size: 18px;
  letter-spacing: 0;
}

.results-panel {
  overflow: hidden;
}

.results-toolbar {
  border-bottom: 1px solid var(--line);
  padding: 16px;
}

.toolbar-actions {
  align-items: end;
  display: flex;
  gap: 10px;
}

.sort-control {
  display: grid;
  gap: 5px;
  min-width: 190px;
}

.table-wrap {
  overflow: auto;
}

table {
  border-collapse: collapse;
  font-size: 14px;
  width: 100%;
}

th {
  background: #f7faf8;
  color: var(--muted);
  font-size: 12px;
  font-weight: 800;
  letter-spacing: 0;
  position: sticky;
  text-align: left;
  text-transform: uppercase;
  top: 0;
  z-index: 1;
}

th,
td {
  border-bottom: 1px solid var(--line);
  padding: 11px 12px;
  vertical-align: middle;
}

tbody tr:hover,
tbody tr.is-selected {
  background: #eef7f4;
}

.link-button {
  background: transparent;
  border: 0;
  color: var(--teal);
  font-weight: 800;
  padding: 0;
}

.type-chip,
.tag,
.status,
.detail-token {
  border-radius: 7px;
  display: inline-flex;
  font-size: 12px;
  font-weight: 800;
  line-height: 1;
  padding: 6px 8px;
  white-space: nowrap;
}

.type-chip {
  background: #edf1ef;
  color: #2d3c36;
}

.status.good {
  background: #ddf1e5;
  color: var(--green);
}

.status.warm {
  background: #fff1dc;
  color: var(--amber);
}

.status.muted,
.detail-token {
  background: #edf1ef;
  color: var(--muted);
}

.muted-text {
  color: var(--muted);
}

.site-label {
  --site-bg: var(--teal-soft);
  --site-color: var(--teal);
  align-items: center;
  background: var(--site-bg);
  border-radius: 7px;
  color: var(--site-color);
  display: inline-flex;
  font-size: 12px;
  font-weight: 900;
  line-height: 1;
  padding: 6px 8px;
  white-space: nowrap;
}

[data-site="airways"] {
  --site-bg: #e41a1c1a;
  --site-color: #E41A1CFF;
}

[data-site="gut"] {
  --site-bg: #377eb81a;
  --site-color: #377EB8FF;
}

[data-site="oral"] {
  --site-bg: #4daf4a1a;
  --site-color: #4DAF4AFF;
}

[data-site="skin"] {
  --site-bg: #984ea31a;
  --site-color: #984EA3FF;
}

[data-site="vagina"] {
  --site-bg: #ff7f001a;
  --site-color: #FF7F00FF;
}

.prevalence-cell {
  display: grid;
  gap: 2px;
}

.prevalence-cell strong,
.observed-row strong,
.prevalence-bar-row strong {
  font-variant-numeric: tabular-nums;
}

.prevalence-cell span {
  color: var(--muted);
  font-size: 12px;
}

.empty-state,
.missing-note {
  color: var(--muted);
  padding: 22px;
}

.empty-state.compact {
  padding: 4px 0 0;
}

.pagination {
  align-items: center;
  display: flex;
  justify-content: space-between;
  padding: 13px 16px;
}

.pagination span {
  color: var(--muted);
  font-size: 13px;
}

.pagination div {
  display: flex;
  gap: 8px;
}

.detail-header {
  margin-bottom: 14px;
}

.detail-close-button {
  align-items: center;
  background: #ffffff;
  border: 1px solid var(--line-strong);
  border-radius: 7px;
  color: var(--muted);
  display: grid;
  flex: 0 0 auto;
  height: 36px;
  justify-content: center;
  padding: 0;
  width: 36px;
}

.detail-close-button:hover {
  background: var(--surface-strong);
  color: var(--teal);
}

.detail-close-button span {
  background:
    linear-gradient(45deg, transparent 42%, currentColor 42%, currentColor 58%, transparent 58%),
    linear-gradient(-45deg, transparent 42%, currentColor 42%, currentColor 58%, transparent 58%);
  height: 12px;
  width: 12px;
}

.eyebrow {
  color: var(--muted);
  display: block;
  font-size: 12px;
  font-weight: 800;
  letter-spacing: 0;
  margin-bottom: 3px;
  text-transform: uppercase;
}

.detail-actions {
  display: flex;
  flex-wrap: wrap;
  gap: 8px;
  margin-bottom: 16px;
}

.detail-actions a,
.mibig-match-list a,
.mibig-match-list .detail-token {
  background: var(--teal-soft);
  border-radius: 7px;
  color: var(--teal);
  font-size: 13px;
  font-weight: 800;
  padding: 7px 9px;
}

.mibig-match-list {
  display: flex;
  flex-wrap: wrap;
  gap: 6px;
}

.detail-stats .mibig-match-list {
  margin-top: 2px;
}

.detail-primary-action {
  margin: 0 0 16px;
}

.primary-link {
  align-items: center;
  background: var(--teal);
  border: 1px solid var(--teal);
  border-radius: 8px;
  color: #ffffff;
  display: flex;
  font-weight: 900;
  justify-content: center;
  min-height: 44px;
  padding: 11px 14px;
  text-decoration: none;
  width: 100%;
}

.primary-link:hover {
  background: #066c61;
  text-decoration: none;
}

.primary-link.is-disabled {
  background: var(--surface-strong);
  border-color: var(--line);
  color: var(--muted);
}

.detail-stats {
  display: grid;
  gap: 8px;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  margin: 0 0 18px;
}

.detail-stats div {
  background: var(--surface-strong);
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 10px;
}

.detail-stats dt {
  color: var(--muted);
  font-size: 11px;
  font-weight: 800;
  letter-spacing: 0;
  text-transform: uppercase;
}

.detail-stats dd {
  font-size: 17px;
  font-weight: 800;
  margin: 3px 0 0;
}

.detail-section {
  border-top: 1px solid var(--line);
  padding: 16px 0;
}

.detail-section h3 {
  font-size: 14px;
  margin-bottom: 10px;
}

.tag-cloud {
  display: flex;
  flex-wrap: wrap;
  gap: 7px;
}

.tag {
  background: var(--blue-soft);
  color: var(--blue-text);
}

.scope-note {
  background: #f7faf8;
  border: 1px solid var(--line);
  border-radius: 7px;
  color: var(--muted);
  font-size: 13px;
  margin-bottom: 10px;
  padding: 9px 10px;
}

.prevalence-groups {
  display: grid;
  gap: 10px;
}

.prevalence-group {
  background: #ffffff;
  border: 1px solid var(--line);
  border-radius: 8px;
  overflow: hidden;
}

.prevalence-group-header {
  align-items: center;
  background: var(--site-bg);
  border-left: 4px solid var(--site-color);
  color: var(--site-color);
  display: flex;
  font-size: 13px;
  font-weight: 900;
  justify-content: space-between;
  padding: 9px 10px;
}

.prevalence-group-header strong {
  background: rgba(255, 255, 255, 0.72);
  border-radius: 7px;
  color: var(--site-color);
  font-size: 12px;
  min-width: 28px;
  padding: 4px 7px;
  text-align: center;
}

.prevalence-subgroups {
  display: grid;
  gap: 0;
}

.prevalence-subgroup {
  border-top: 1px solid var(--line);
}

.prevalence-group-header + .prevalence-subgroups > .prevalence-subgroup:first-child {
  border-top: 0;
}

.prevalence-subgroup-header {
  align-items: center;
  background: #f7faf8;
  color: var(--text);
  display: flex;
  font-size: 12px;
  font-weight: 900;
  justify-content: space-between;
  padding: 8px 10px;
}

.prevalence-subgroup-header span {
  color: var(--site-color);
}

.prevalence-subgroup-header strong {
  background: var(--site-bg);
  border-radius: 7px;
  color: var(--site-color);
  font-size: 11px;
  min-width: 26px;
  padding: 3px 7px;
  text-align: center;
}

.prevalence-bars {
  display: grid;
  gap: 8px;
  padding: 10px;
}

.prevalence-bar-row {
  align-items: center;
  display: grid;
  gap: 8px;
  grid-template-columns: minmax(112px, 1.05fr) minmax(72px, 1fr) 48px;
}

.prevalence-bar-track {
  background: #edf1ef;
  border-radius: 99px;
  height: 8px;
  overflow: hidden;
}

.prevalence-bar-fill {
  background: var(--site-color);
  border-radius: inherit;
  height: 100%;
  min-width: 2px;
}

.prevalence-bar-row strong {
  color: var(--site-color);
  font-size: 13px;
  text-align: right;
}

.observed-list {
  display: grid;
  gap: 8px;
}

.observed-row {
  align-items: center;
  border: 1px solid var(--line);
  border-radius: 7px;
  display: grid;
  gap: 8px;
  grid-template-columns: minmax(112px, 0.9fr) minmax(0, 1.3fr) auto;
  padding: 8px 10px;
}

.observed-study,
.observed-site {
  overflow: hidden;
  text-overflow: ellipsis;
  white-space: nowrap;
}

.observed-study {
  font-weight: 800;
}

.observed-site {
  color: var(--muted);
}

.observed-row strong {
  color: var(--teal);
}

@media (max-width: 1180px) {
  .shell {
    grid-template-columns: var(--sidebar-width, 320px) minmax(0, 1fr);
  }

  .shell.has-detail {
    grid-template-columns: var(--sidebar-width, 320px) minmax(0, 1fr);
  }

  .detail-resizer {
    display: none;
  }

  .detail-panel {
    border-left: 0;
    border-top: 1px solid var(--line);
    grid-column: 1 / -1;
    height: auto;
    position: static;
  }
}

@media (max-width: 820px) {
  .shell {
    display: block;
  }

  .sidebar,
  .detail-panel {
    border: 0;
    height: auto;
    position: static;
  }

  .sidebar {
    border-bottom: 1px solid var(--line);
  }

  .shell.is-sidebar-collapsed .sidebar {
    padding: 12px 16px;
  }

  .sidebar-top,
  .shell.is-sidebar-collapsed .sidebar-top {
    grid-template-columns: minmax(0, 1fr) 38px;
    justify-items: stretch;
    margin-bottom: 14px;
  }

  .workspace {
    padding: 16px;
  }

  .active-filters {
    align-items: stretch;
    flex-direction: column;
  }

  .filter-chip {
    max-width: 100%;
  }

  .panel-header,
  .results-toolbar,
  .toolbar-actions,
  .pagination {
    align-items: stretch;
    flex-direction: column;
  }

  .sort-control {
    min-width: 0;
  }

  .table-wrap {
    max-width: 100%;
  }
}